NEUROPROTECTIVE EFFECTS OF RILUZOLE ON N-METHYL-D-ASPARTATE-INDUCED OR VERATRIDINE-INDUCED NEUROTOXICITY IN RAT HIPPOCAMPAL SLICES

被引：73

作者：

MALGOURIS, C

DANIEL, M

DOBLE, A

机构：

[1] Rhône-Poulenc Rorer, Centre de Recherche de Vitry-Alfortville, 13, quai Jules Guesde, BP 14

来源：

NEUROSCIENCE LETTERS | 1994年 / 177卷 / 1-2期

关键词：

HIPPOCAMPAL SLICE; GLUTAMATE; VERATRIDINE; NEUROTOXICITY; LACTATE DEHYDROGENASE RELEASE; HISTOLOGY;

D O I：

10.1016/0304-3940(94)90053-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The neuroprotective activity of riluzole has been studied on N-methyl-D-aspartate (NMDA)- or veratridine-induced toxicity in immature rat hippocampal slices. Neurodegeneration was assessed by the measurement of LDH release and histology. Veratridine-induced LDH release can be inhibited by 100 mu M riluzole (-90%) and by tetrodotoxin (1 mu M). Riluzole markedly reduced (-59%) the NMDA-induced LDH release and this protective effect was confirmed by histology. Riluzole inhibited the NMDA-induced LDH release in the presence of tetrodotoxin. Moreover, a pretreatment with pertussis toxin (1 mu g/ml) abolished the effect of riluzole against NMDA-induced neurotoxicity. These results support the view that the neuroprotective properties of riluzole could be exerted via two distinct mechanisms of action.

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页码：95 / 99

页数：5

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