A REFINED PHYSICAL MAP OF THE LONG ARM OF HUMAN CHROMOSOME-16

被引：14

作者：

CHEN, LZ

HARRIS, PC

APOSTOLOU, S

BAKER, E

HOLMAN, K

LANE, SA

NANCARROW, JK

WHITMORE, SA

STALLINGS, RL

HILDEBRAND, CE

RICHARDS, RI

SUTHERLAND, GR

CALLEN, DF

机构：

[1] JOHN RADCLIFFE HOSP,INST MOLEC MED,OXFORD OX3 9DU,ENGLAND

[2] UNIV CALIF LOS ALAMOS SCI LAB,DIV LIFE SCI,LOS ALAMOS,NM 87545

来源：

GENOMICS | 1991年 / 10卷 / 02期

关键词：

D O I：

10.1016/0888-7543(91)90313-4

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Mapping of 33 anonymous DNA probes and 12 genes to the long arm of chromosome 16 was achieved by the use of 14 mouse/human hybrid cell lines and the fragile site FRA16B. Two of the hybrid cell lines contained overlapping interstitial deletions in bands q21 and q22.1. The localization of the 12 genes has been refined. The breakpoints present in the hybrids, in conjunction with the fragile site, can potentially divide the long arm of chromosome 16 into 16 regions. However, this was reduced to 14 regions because in two instances there were no probes or genes that mapped between pairs of breakpoints. © 1991.

引用

页码：308 / 312

页数：5

共 21 条

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