COMPARISON OF 3 SPECIES OF DIETARY FISH - EFFECTS ON SERUM CONCENTRATIONS OF LOW-DENSITY-LIPOPROTEIN CHOLESTEROL AND APOLIPOPROTEIN IN NORMOTRIGLYCERIDEMIC SUBJECTS

Limited information is available comparing the effect of different species of fish on serum low-density-lipoprotein-cholesterol (LDL-C) and apolipoprotein B (apo B) concentrations. We fed 21 normotriglyceridemic males diets containing different species of fish (200 g Dover sole, Chinook salmon, or sablefish) for 18 d in a three-period crossover design. Concentrations of apo B and LDL-C rose on the salmon and sablefish diets compared with the sole diet (P = 0.02 for apo B, 0.08 for LDL-C). These increases were parallel to each other: apo B rose 14% and LDL-C rose 16% on the salmon diet and 17% and 14%, respectively, on the sablefish diet compared with the diet consumed before the study. These results suggest that the consumption of fish with a moderate amounts of n-3 fatty acids may cause a deleterious rise in LDL-C and apo B concentrations in normotriglyceridemic males.