IDENTIFICATION OF A GENETIC-LOCUS INVOLVED IN THE BIOSYNTHESIS OF N-ACETYL-D-MANNOSAMINE, A PRECURSOR OF THE (ALPHA-2-]8)-LINKED POLYSIALIC ACID CAPSULE OF SEROGROUP-B NEISSERIA-MENINGITIDIS

被引：34

作者：

SWARTLEY, JS

STEPHENS, DS

机构：

[1] EMORY UNIV, SCH MED, DEPT MED, DIV INFECT DIS, ATLANTA, GA 30322 USA

[2] EMORY UNIV, SCH MED, DEPT MICROBIOL & IMMUNOL, ATLANTA, GA 30322 USA

[3] VET ADM MED CTR, ATLANTA, GA 30033 USA

来源：

JOURNAL OF BACTERIOLOGY | 1994年 / 176卷 / 05期

关键词：

D O I：

10.1128/jb.176.5.1530-1534.1994

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We characterized the genetic defect of a capsule-deficient serogroup B meningococcal strain created by Tn916 mutagenesis. The transposon insertion interrupts a capsule biosynthesis gene, synX, which is involved in the production of N-acetyl-D-mannosamine, a precursor of the (alpha 2-->8)-linked polysialic acid capsule of serogroup B meningococci.

引用

页码：1530 / 1534

页数：5

共 27 条

[1]

BLACKLOW RS, 1962, J BIOL CHEM, V237, P3520

[2] DEFINED AGAR MEDIUM FOR GENETIC TRANSFORMATION OF NEISSERIA MENINGITIDIS [J].