INVITRO ISOLATION OF A NEUTRALIZATION ESCAPE MUTANT OF EQUINE INFECTIOUS-ANEMIA VIRUS (EIAV)

被引：51

作者：

RWAMBO, PM

ISSEL, CJ

HUSSAIN, KA

MONTELARO, RC

机构：

[1] LOUISIANA STATE UNIV,LOUISIANA AGR EXPT STN,CTR AGR,DEPT VET SCI,BATON ROUGE,LA 70803

[2] LOUISIANA STATE UNIV,LOUISIANA AGR EXPT STN,CTR AGR,DEPT BIOCHEM,BATON ROUGE,LA 70803

[3] LOUISIANA STATE UNIV,SCH VET MED,DEPT VET MICROBIOL & PARASITOL,BATON ROUGE,LA 70803

来源：

ARCHIVES OF VIROLOGY | 1990年 / 111卷 / 3-4期

关键词：

D O I：

10.1007/BF01311062

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A neutralization escape mutant (A/1 E) of equine infectious anemia virus was isolated after 13 passages in cell culture in the presence of serum containing antibodies to type- and group-specific determinants of EIAV envelope glycoproteins. Loss of neutralization by the selecting serum correlated with loss of two epitopes in the major envelope glycoprotein gp90 of A/1 E which were present in a parallel variant isolated from a persistently infected pony. © 1990 Springer-Verlag.

引用

页码：275 / 280

页数：6

共 12 条

[1]

AMBORSKI GF, 1979, AM J VET RES, V40, P302

[2]

CHEEVERS WP, 1985, REV INFECT DIS, V7, P83

[3] ANTIGENIC ANALYSIS OF EQUINE INFECTIOUS-ANEMIA VIRUS (EIAV) VARIANTS BY USING MONOCLONAL-ANTIBODIES - EPITOPES OF GLYCOPROTEIN GP90 OF EIAV STIMULATE NEUTRALIZING ANTIBODIES [J].