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INITIATION AND PROCESSING OF 2 KAPPA-IMMUNOGLOBULIN GERM LINE TRANSCRIPTS IN MOUSE B-CELLS

被引：56
作者：
MARTIN, DJ
VANNESS, BG
机构：
[1] UNIV MINNESOTA,DEPT BIOCHEM,BOX 206 UMHC,MINNEAPOLIS,MN 55455
[2] UNIV MINNESOTA,INST HUMAN GENET,MINNEAPOLIS,MN 55455
[3] UNIV IOWA,DEPT BIOCHEM,IOWA CITY,IA 52242
来源：
MOLECULAR AND CELLULAR BIOLOGY | 1990年 / 10卷 / 05期
关键词：
D O I：
10.1128/MCB.10.5.1950
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The splicing patterns and sequences of two processed kappa immunoglobulin germ line mRNAs are presented. A 1.1-kilobase (kb) mRNA appeared to be derived from splicing of the previously characterized 8.4-kb germ line transcript, while a 0.8-kb mRNA was the splice product of a second 4.7-kb germ line transcript that initiated 50 base pairs upstream of Jκ1. The interaction of the two kappa germ line promoters with nuclear binding factors is also examined. The potential role of these germ line transcripts in establishing the rearrangement potential of the locus is discussed.
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页码：1950 / 1958
页数：9
相关论文
共 54 条
[1]   SEQUENCE REQUIREMENTS FOR SPLICING OF HIGHER EUKARYOTIC NUCLEAR PRE-MESSENGER-RNA [J].
AEBI, M ;
HORNIG, H ;
PADGETT, RA ;
REISER, J ;
WEISSMANN, C .
CELL, 1986, 47 (04) :555-565
[2]   REGULATION OF GENOME REARRANGEMENT EVENTS DURING LYMPHOCYTE DIFFERENTIATION [J].
ALT, FW ;
BLACKWELL, TK ;
DEPINHO, RA ;
RETH, MG ;
YANCOPOULOS, GD .
IMMUNOLOGICAL REVIEWS, 1986, 89 :5-30
[3]   DEVELOPMENT OF THE PRIMARY ANTIBODY REPERTOIRE [J].
ALT, FW ;
BLACKWELL, TK ;
YANCOPOULOS, GD .
SCIENCE, 1987, 238 (4830) :1079-1087
[4]  
Alwine J C, 1979, Methods Enzymol, V68, P220
[5]   THE ROLE OF THE KAPPA-ENHANCER AND ITS BINDING-FACTOR NF-KAPPA-B IN THE DEVELOPMENTAL REGULATION OF KAPPA-GENE TRANSCRIPTION [J].
ATCHISON, ML ;
PERRY, RP .
CELL, 1987, 48 (01) :121-128
[6]   PURIFICATION OF BIOLOGICALLY-ACTIVE GLOBIN MESSENGER-RNA BY CHROMATOGRAPHY ON OLIGOTHYMIDYLIC-ACID-CELLULOSE [J].
AVIV, H ;
LEDER, P .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1972, 69 (06) :1408-&
[7]   RECOMBINATION BETWEEN IMMUNOGLOBULIN VARIABLE REGION GENE SEGMENTS IS ENHANCED BY TRANSCRIPTION [J].
BLACKWELL, TK ;
MOORE, MW ;
YANCOPOULOS, GD ;
SUH, H ;
LUTZKER, S ;
SELSING, E ;
ALT, FW .
NATURE, 1986, 324 (6097) :585-589
[8]  
BLACKWELL TK, 1989, J BIOL CHEM, V264, P10327
[9]   MECHANISMS THAT REGULATE IMMUNOGLOBULIN GENE-EXPRESSION [J].
CALAME, KL .
ANNUAL REVIEW OF IMMUNOLOGY, 1985, 3 :159-195
[10]   RNA SPLICING GENERATES A VARIANT LIGHT CHAIN FROM AN ABERRANTLY REARRANGED K-GENE [J].
CHOI, E ;
KUEHL, M ;
WALL, R .
NATURE, 1980, 286 (5775) :776-779
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