ELEVATION IN RELATIVE LEVELS OF BRAIN MEMBRANE UNSATURATED FATTY-ACIDS IN ALZHEIMERS-DISEASE - HIGH-RESOLUTION PROTON SPECTROSCOPIC STUDIES OF MEMBRANE LIPID EXTRACTS

被引：22

作者：

KWEE, IL

NAKADA, T

ELLIS, WG

机构：

[1] UNIV CALIF DAVIS,DEPT NEUROL,DAVIS,CA 95616

[2] UNIV CALIF DAVIS,DEPT PATHOL,DAVIS,CA 95616

来源：

MAGNETIC RESONANCE IN MEDICINE | 1991年 / 21卷 / 01期

关键词：

D O I：

10.1002/mrm.1910210108

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Unsaturation indices of cerebral cortex membrane phospholipids in Alzheimer's disease were determined utilizing high resolution proton nuclear magnetic resonance (NMR) spectroscopy of lipid extracts. The unsaturation index of Alzheimer's brain was found to be significantly higher (P < 0.01) than that of age‐matched controls. The study provides further support for the hypothesis that alteration in phospholipid metabolism, especially an elevation in unsaturated fatty acids, may play a role in the pathogenesis of Alzheimer's disease. © 1991 Academic Press, Inc. Copyright © 1991 Wiley‐Liss, Inc., A Wiley Company

引用

页码：49 / 54

页数：6

共 22 条

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