MATCHED GROUP-STUDY OF PREENUCLEATION RADIOTHERAPY VERSUS ENUCLEATION ALONE FOR PRIMARY MALIGNANT-MELANOMA OF THE CHOROID AND CILIARY BODY

被引:17
作者
AUGSBURGER, JJ
LAURITZEN, K
GAMEL, JW
LOWRY, JC
BRADY, LW
机构
[1] HAHNEMANN UNIV, COLL MED, DEPT RADIAT ONCOL & NUCL MED, PHILADELPHIA, PA 19102 USA
[2] UNIV LOUISVILLE, HLTH SCI CTR, SCH MED, DEPT OPHTHALMOL & VISUAL SCI, LOUISVILLE, KY 40202 USA
[3] VET ADM MED CTR, LOUISVILLE, KY 40202 USA
来源
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS | 1990年 / 13卷 / 05期
关键词
D O I
10.1097/00000421-199010000-00004
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
We report the results of a nonrandomized, matched group survival study comparing 29 patients with a choroidal or ciliary body melanoma managed by enucleation alone to 29 patients managed by enucleation following external beam ocular irradiation (20 Gy in five fractions over 5-7 days just prior to enucleation). Variables on which the patients in the two groups were matched included age at time of enucleation, largest linear tumor dimension, location of the anterior tumor margin relative to the equator and ora serrata, melanoma cell type, and extrascleral tumor extension. The cumulative 5-year survival in the enucleation alone group was 57.9% (SE = 9.9%), whereas that in the preenucleation radiation therapy group was 63.9% (SE = 12.2%). This difference is not statistically significant (p > 0.5, Mantel-Haenszel test). The authors discuss the strengths and limitations of their study and the implications of their results.
引用
收藏
页码:382 / 387
页数:6
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