A NOVEL LYSINE-PROTECTING PROCEDURE FOR CONTINUOUS-FLOW SOLID-PHASE SYNTHESIS OF BRANCHED PEPTIDES

被引：182

作者：

BYCROFT, BW

CHAN, WC

CHHABRA, SR

HONE, ND

机构：

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1993年 / 09期

关键词：

D O I：

10.1039/c39930000778

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new amine protecting group which can be used orthogonally with both Fmoc and Boc protection is reported; by employing lysine protected appropriately as the branching motif, a 34 residue di-epitopic peptide has been constructed by continuous flow solid phase peptide synthesis.

引用

页码：778 / 779

页数：2

共 9 条

[1]

BYCROFT BW, J CHEM SOC CHEM COMM

[2]

GUM JR, 1989, J BIOL CHEM, V264, P4680

[3]

HANCOCK WS, 1976, ANAL BIOCHEM, V71, P260, DOI 10.1016/0003-2697(76)90034-8

[4]

MACHLEIDT H, 1964, LIEBIGS ANN CHEM, V679, P9