CREATININE FOR ESTIMATION OF GLOMERULAR-FILTRATION RATE

被引：29

作者：

HELLERSTEIN, S

ALON, U

WARADY, BA

机构：

[1] Department of Pediatrics, University of Missouri-Kansas City School of Medicine, Kansas City, 64 108, MO

[2] Section of Pediatric Nephrology, The Children's Mercy Hospital, Kansas City, 64 108, MO

来源：

PEDIATRIC NEPHROLOGY | 1992年 / 6卷 / 06期

关键词：

GLOMERULAR FILTRATION RATE; INULIN CLEARANCE; CREATININE CLEARANCE; PLASMA CREATININE; CALCULATED CREATININE CLEARANCE;

D O I：

10.1007/BF00866485

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The aim of this study was to evaluate the plasma creatinine concentration (P(Cr)) and creatinine clearance (C(Cr)) for estimation of glomerular filtration rate (GFR). Inulin clearance (C(in)) was used as the reference standard for GFR. Thirty-nine concurrent C(in) and C(Cr) studies provided data for comparing C(in) with the measured C(Cr) and with the calculated C(Cr) (calc-C(Cr)). (Calc-C(Cr) = k.L/P(Cr), where L = height in centimeters and k is the proportionality constant.) Thirty-one children 5.3-20.8 years of age, with C(in) ranging from 2.8 to 138.8 ml/min per 1.73 m2, participated in these studies at The Children's Mercy Hospital. The measured C(Cr) was 16.7 +/- 10.3 ml/min per 1.73 m2 (P <0.001) greater than the C(in), and the calc-C(Cr) overestimated C(in) by a mean of 31.6 +/- 20.8 ml/min per 1.73 m2 (P <0.001). Although there is good correlation between C(in) and C(Cr) (r = 0.96), and C(in) and calc-C(Cr) (r = 0.90), the 95% confidence intervals are quite broad. Hence, the C(Cr) and the calc-C(Cr), derived using Schwartz values for k, consistently overestimate GFR. However, if the k value in the equation GFR = k.L/P(Cr) is derived from k = C(in)/L, rather than from k = C(Cr).P(Cr)/L, a more accurate estimate of GFR may be obtained.

引用

页码：507 / 511

页数：5

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