Maternal HIV infection, drug use, and growth of uninfected children in their first 3 years

被引:13
作者
Ross, A
Raab, GM
Mok, J
Gilkison, S
Hamilton, B
Johnstone, FD
机构
[1] NAPIER UNIV, DEPT MATH, APPL STAT GRP, EDINBURGH, MIDLOTHIAN, SCOTLAND
[2] CITY HOSP, REG INFECT DIS UNIT, EDINBURGH, MIDLOTHIAN, SCOTLAND
[3] UNIV EDINBURGH, DEPT OBSTET & GYNAECOL, EDINBURGH, MIDLOTHIAN, SCOTLAND
关键词
substance abuse; HIV seropositivity; growth;
D O I
10.1136/adc.73.6.490
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Objective-To determine the separate effects of maternal HIV infection and drug use during pregnancy on growth of uninfected children in their first 3 years. Design-Retrospective analysis of measurements from health visitor records made during routine child health surveillance at 6 weeks, 10 months, and 3 years of age. Multilevel analysis allowed for between-infant variation in fitted growth Lines, and adjustment for other factors. Growth was described in terms of an intercept (z score at term) and growth slopes (change in z score per year) up to, and from, 3 months. Subjects-290 case babies delivered in Edinburgh hospitals to women who reported injection drug use by either themselves or their HIV infected partner, and 186 community controls. A total of 131 (45%) of the case babies were born to women who used drugs, predominantly opiates, during pregnancy and 93 (32%) to HN infected women. The eight infected children were excluded from analysis. Main outcome measures-Age and sex standardised z scores for height, weight, and body mass index.
引用
收藏
页码:490 / 495
页数:6
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