REFINED LOCALIZATION OF THE ASPARAGINE SYNTHETASE GENE (ASNS) TO CHROMOSOME-7, REGION Q21.3, AND CHARACTERIZATION OF THE SOMATIC-CELL HYBRID LINE 4AF/106/KO15

被引：26

作者：

HENG, HHQ

SHI, XM

SCHERER, SW

ANDRULIS, IL

TSUI, LC

机构：

[1] HOSP SICK CHILDREN,RES INST,DEPT GENET,TORONTO M5G 1X8,ON,CANADA

[2] UNIV TORONTO,DEPT MOLEC & MED GENET,TORONTO,ON,CANADA

[3] MT SINAI HOSP,RES INST,TORONTO,ON,CANADA

来源：

CYTOGENETICS AND CELL GENETICS | 1994年 / 66卷 / 02期

关键词：

D O I：

10.1159/000133685

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We have mapped the asparagine synthetase gene (ASNS) to 7q21.3 by fluorescence in situ hybridization. While this study refined the localization of the gene, it also revealed st rearrangement in a somatic cell hybrid line which was used in previous ASNS mapping. Using additional probes from other regions of human chromosome 7, we showed that this cell line (4AF/106/K015) contained a rearranged chromosome 7 in which a segment of the long arm was apparently duplicated and inserted into the short arm. Caution should be used therefore when interpreting data obtained from this cell line for gene mapping studies.

引用

页码：135 / 138

页数：4

共 17 条

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