CELL-MEMBRANE CHANGES IN BRAINS MANIFESTING SENILE PLAQUES - AN IMMUNOHISTOCHEMICAL STUDY OF GM1 MEMBRANOUS GANGLIOSIDE

被引：15

作者：

IWAMOTO, N

SUZUKI, Y

MAKINO, Y

HAGA, C

KOSAKA, K

IIZUKA, R

机构：

[1] UNIV SHIZUOKA,SCH PHARMACEUT SCI,DEPT BIOCHEM,SHIZUOKA,JAPAN

[2] TOKYO METROPOLITAN MATSUZAWA HOSP,TOKYO,JAPAN

[3] PSYCHIAT RES INST TOKYO,DEPT NEUROPATHOL,TOKYO 156,JAPAN

来源：

BRAIN RESEARCH | 1990年 / 522卷 / 01期

关键词：

Alzheimer-type dementia; Astrocyte; Ganglioside GM[!sub]1[!/sub; Membrane; Senile plaque;

D O I：

10.1016/0006-8993(90)91592-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To investigate structural changes in cell membranes of the Alzheimer-type dementia (ATD) brain, we immunostained for GM1 ganglioside which is a major component of the cell membrane. Our results have shown that astrocytic membranes and senile plaques (SPs) have the same immunoreactivity against the monoclonal anti-ganglioside GM1 antibody. Moreover, the astrocytic processes within the SPs were altered and their abnormal membranes seemed to contribute to the formation of SPs. © 1990.

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页码：152 / 156

页数：5

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