ISOLATION AND CHARACTERIZATION OF CULMORIN DERIVATIVES PRODUCED BY FUSARIUM-CULMORUM CMI-14764

被引：28

作者：

KASITU, GC

APSIMON, JW

BLACKWELL, BA

FIELDER, DA

GREENHALGH, R

MILLER, JD

机构：

[1] AGR CANADA,PLANT RES CTR,OTTAWA K1A 0C6,ONTARIO,CANADA

[2] CARLETON UNIV,OTTAWA CARLETON CHEM INST,OTTAWA K1S 5B6,ONTARIO,CANADA

来源：

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE | 1992年 / 70卷 / 05期

关键词：

D O I：

10.1139/v92-168

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Liquid culture fermentations of Fusarium culmorum yield a wide variety of secondary metabolites. In addition to known isoprenoids, such as the trichothecenes and modified trichothecenes, four new derivatives of culmorin have been isolated and characterized by spectral analysis. These compounds are 15-hydroxyculmorone (7), and 5-hydroxy- (8), 12-hydroxy- (10), and 15-hydroxyculmorin (9). The structure of culmorone is confirmed. The biosynthesis of culmorin from farnesyl pyrophosphate is substantiated through the use of C-13-acetate and the oxidation of these derivatives is discussed.

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页码：1308 / 1316

页数：9

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