PROTON-PUMP INHIBITION AND GASTRIC GIARDIASIS - A CAUSAL OR CASUAL ASSOCIATION

被引:21
作者
REYNAERT, H
FERNANDES, E
BOURGAIN, C
SMEKENS, L
DEVIS, G
机构
[1] Department of Gastroenterology and Hepatology, University Hospital AZ-VUB, Brussels, B-1090
[2] Department of Pathology, University Hospital AZ-VUB, Brussels, B-1090
关键词
GASTRIC GIARDIASIS; PROTON-PUMP INHIBITORS;
D O I
10.1007/BF02349646
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Two patients who developed gastric giardiasis after 2 weeks of treatment with omeprazole 20mg b.i.d. followed by omeprazole 20mg per day for 2-6 weeks are described. In one patient, gastric giardiasis occurred in the presence of only mild intestinal metaplasia. In the other patient, Giardia lamblia infection had resolved 4 weeks after the cessation of omeprazole treatment, which, to our knowledge, is the first case reported in the literature. It is tempting to speculate that gastric giardiasis can develop in the absence of mucosal abnormalities during hypochlorhydria induced by treatment with a high dose of a proton-pump inhibitor. Specific treatment may not be required if the drug can be stopped and no other gastric disease causing hypochlorhydria is present.
引用
收藏
页码:775 / 778
页数:4
相关论文
共 10 条
[1]  
Farthing M.J.G., Diarrhoeal disease: Current concepts and future challenges. Pathogenesis of giardiasis, Trans R Soc Trop Med Hyg, 87, pp. 17-21, (1993)
[2]  
Doglioni C., De Boni M., Cielo R., Et al., Gastric giardiasis, J Clin Pathol, 45, pp. 964-967, (1992)
[3]  
Oberhuber G., Stolte M., Bethke B., Et al., Gastric giardiasis: Analysis of biopsy specimens from 191 patients infected with Giardia lamblia, Eur J Gastroenterol Hepatol, 5, pp. 357-360, (1993)
[4]  
Quincey C., James P.D., Steele R.J.C., Chronic giardiasis of the stomach, J Clin Pathol, 45, pp. 1039-1041, (1992)
[5]  
Klinkenberg-Knol E.C., Meuwissen S.G.M., Combined gastric and oesophageal 24-h pH monitoring and oesophageal manometry in patients with reflux disease resistant to treatment with omeprazole, Aliment Pharmacol Ther, 4, pp. 485-495, (1990)
[6]  
Hannan A., Weil J., Broom C., Et al., Effects of oral pantoprazole on 24-h intragastric acidity and plasma gastrin profiles, Aliment Pharmacol Ther, 6, pp. 373-380, (1992)
[7]  
Damman H.G., von zur Muhlen A., Balks H.J., Et al., The effects of lansoprazole, 30 or 60 mg daily, on gastric pH and on endocrine function in healthy volunteers, Aliment Pharmacol Ther, 7, pp. 191-196, (1993)
[8]  
Hoskins L.C., Winawer S.Y., Broitman S.A., Et al., Clinical giardiasis and intestinal malabsorption, Gastroenterology, 53, pp. 265-279, (1967)
[9]  
Cook G.C., Infective gastroenteritis and its relationship to reduced gastric acidity, Scand J Gastroenterol, 20 S, pp. 77-83, (1985)
[10]  
Yardley J.H., Takano J., Hendrix T.R., Epithelial and other mucosal lesions of the jejunum in giardiasis. Jejunal biopsy studies, Bull Johns Hopkins Hosp, 115, pp. 389-406, (1964)