STEARYL-NORLEUCINE-VASOACTIVE INTESTINAL PEPTIDE (VIP) - A NOVEL VIP ANALOG FOR NONINVASIVE IMPOTENCE TREATMENT

被引：45

作者：

GOZES, I ^{[1
]}

RESHEF, A ^{[1
]}

SALAH, D ^{[1
]}

RUBINRAUT, S ^{[1
]}

FRIDKIN, M ^{[1
]}

机构：

[1] WEIZMANN INST SCI, DEPT ORGAN CHEM, REHOVOT, ISRAEL

来源：

ENDOCRINOLOGY | 1994年 / 134卷 / 05期

关键词：

D O I：

10.1210/en.134.5.2121

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The present report relates to pharmaceutical composition for the treatment of male impotence. The transdermal application of a potent derivative of vasoactive intestinal peptide (VIP) coupled to a suitable hydrophobic moiety (e.g. stearyl-VIP) in a suitable ointment composition (e.g. Sefsol) enhances sexual activity and erection formation in a variety of impotence models in rats (sterile rats, diabetic rats, and animals with high blood pressure). Furthermore, exchange of the methionine in position 17 with norleucine enhances biological activity. Thus, stearyl-Nle(17)-VIP may be considered useful for the treatment of impotence.

引用

页码：2121 / 2125

页数：5

共 23 条

[1] IS VASOACTIVE INTESTINAL POLYPEPTIDE THE PRINCIPAL TRANSMITTER INVOLVED IN HUMAN PENILE ERECTION [J].