MOLECULAR MODELING STUDIES ON 11-BETA-AMINOETHOXYPHENYL AND 7-ALPHA-AMINOETHOXYPHENYL ESTRADIOLS - EVIDENCE SUGGESTING A COMMON HYDROPHOBIC POCKET IN ESTROGEN-RECEPTOR

被引：21

作者：

POUPAERT, JH

LAMBERT, DM

VAMECQ, J

ABULHAJJ, YJ

机构：

[1] UNIV CATHOLIQUE LOUVAIN,ECOLE PHARM,BRUSSELS,BELGIUM

[2] UNIV MINNESOTA,DEPT MED CHEM,MINNEAPOLIS,MN 55455

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 08期

关键词：

D O I：

10.1016/0960-894X(95)00128-G

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Molecular modeling studies were performed on 11 beta and 7 alpha-aminoethoxyphenyl estradiols to determine whether these compounds may interact with the same receptor subsite. Energy minimization and molecular dynamics studies lend support to this hypothesis.

引用

页码：839 / 842

页数：4

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