AUTOANTIBODIES TO PYRUVATE-DEHYDROGENASE COMPLEX IN PATIENTS WITH SYSTEMIC-SCLEROSIS - POSSIBLE ROLE OF ANTI-E1-ALPHA ANTIBODY AS A SEROLOGIC INDICATOR FOR DEVELOPMENT OF PRIMARY BILIARY-CIRRHOSIS

被引：21

作者：

FUJIMOTO, M ^{[1
]}

SATO, S ^{[1
]}

IHN, H ^{[1
]}

KIKUCHI, K ^{[1
]}

TAMAKI, K ^{[1
]}

TAKEHARA, K ^{[1
]}

机构：

[1] UNIV TOKYO,FAC MED,DEPT DERMATOL,BUNKYO KU,TOKYO 113,JAPAN

来源：

ARTHRITIS AND RHEUMATISM | 1995年 / 38卷 / 07期

关键词：

D O I：

10.1002/art.1780380715

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective, To determine the prevalence and clinical significance of anti-pyruvate dehydrogenase complex (anti-PDC) antibodies in systemic sclerosis (SSc). Methods, Serum samples from patients with limited cutaneous SSc (n = 81) or diffuse cutaneous SSc (n = 63) were examined for anti-PDC antibodies by enzyme-linked immunosorbent assay (ELISA) and immnnoblotting. Results, IgG- and/or IgM-isotype anti-PDC antibodies were demonstrated by ELISA in 26 of 144 patients with SSc (18%), By immunoblotting, 19 patients had IgG anti-PDC antibodies. Among these patients with IgG anti-PDC antibodies, antibody to the E1 alpha subunit was significantly associated with the presence of laboratory abnormalities typical of primary biliary cirrhosis (PBC). Conclusion, Antibody to the E1 alpha subunit of PDC may be a serologic indicator for the development of PBC in patients with SSc.

引用

页码：985 / 989

页数：5

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