BRAIN MACROPHAGES STIMULATE NEURITE GROWTH AND REGENERATION BY SECRETING THROMBOSPONDIN

被引：124

作者：

CHAMAK, B

MORANDI, V

MALLAT, M

机构：

[1] COLL FRANCE, INSERM, U114, F-75231 PARIS 05, FRANCE

[2] HOP ST LOUIS, INSERM, U353, PARIS, FRANCE

来源：

JOURNAL OF NEUROSCIENCE RESEARCH | 1994年 / 38卷 / 02期

关键词：

MICROGLIA; RAT; DEVELOPMENT; KAINIC ACID LESION;

D O I：

10.1002/jnr.490380213

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The presence of macrophages in the developing or lesioned central nervous system (CNS) led us to study the influence of these cells on neuronal growth. Macrophages were isolated from embryonic rat brain and we observed that factors released in vitro by these cells stimulate neurite growth and regeneration of cultured CNS neurons. This effect was inhibited by antibodies directed against thrombospondin, an extracellular matrix protein that we found to be synthesized and released by brain macrophages. Immunodetection of thrombospondin in the adult rat brain lesioned by kainic acid confirmed the production of this protein by brain macrophages and indicated an early intraparenchymal accumulation of thrombospondin following injury. These results suggest that brain macrophages contribute actively to neurite growth or regeneration during the development or in pathological contexts. (C) 1994 Wiley-Liss, Inc.

引用

页码：221 / 233

页数：13

共 61 条

[1] BRAIN NEURONS DEVELOP IN A SERUM AND GLIAL FREE ENVIRONMENT - EFFECTS OF TRANSFERRIN, INSULIN, INSULIN-LIKE GROWTH FACTOR-I AND THYROID-HORMONE ON NEURONAL SURVIVAL, GROWTH AND DIFFERENTIATION [J].