BIOSYNTHESIS OF XANTHOFUSIN, A TETRONIC ACID METABOLITE OF FUSICOCCUM SP

被引:4
作者
BREINHOLT, J
DAMTOFT, S
FREDERIKSEN, LB
HANSEN, LBL
JENSEN, SR
机构
[1] TECH UNIV DENMARK,DEPT ORGAN CHEM,DK-2800 LYNGBY,DENMARK
[2] NOVO NORDISK AS,DIV PLANT PROTECT,DK-2880 BAGSVAERD,DENMARK
关键词
FUSICOCCUM; XANTHOFUSIN; TETRONIC ACIDS; BIOSYNTHESIS;
D O I
10.1016/0031-9422(95)00175-7
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Incorporation experiments with [Me-H-2(3)]methionine, [1-C-13]- and [1,2-C-13(2)]- acetate showed that the methyl groups of xanthofusin are derived from methionine, and the remaining carbon atoms are derived from three intact acetate units. Incorporation of C-13-labelled 1,3-dihydroxy-2,4-dimethylbenzene shows that this is a probable intermediate. Three possible pathways are discussed, namely a triketide origin of xanthofusin, a route via a tetraketide but with loss of the starter unit and, finally, a route including a triketide with a malonate starter unit.
引用
收藏
页码:1359 / 1362
页数:4
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