6-(SUBSTITUTED METHYLENE)PENEMS, POTENT BROAD-SPECTRUM INHIBITORS OF BACTERIAL BETA-LACTAMASE .1. RACEMIC 6-ETHYLIDENEPENEMS

被引：12

作者：

BASKER, MJ ^{[1
]}

OSBORNE, NF ^{[1
]}

机构：

[1] BEECHAM PHARMACEUT,CHEMOTHERAPY RES CTR,BETCHWORTH RH3 7AJ,SURREY,ENGLAND

来源：

JOURNAL OF ANTIBIOTICS | 1990年 / 43卷 / 01期

关键词：

D O I：

10.7164/antibiotics.43.70

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The dehydration of various 6-(1-hydroxyethyl)penems to give E- and Z-6-ethylidenepenems is described. Both isomers have been shown to be potent broad spectrum inhibitors of bacterial β-lactamases capable of reducing the MIC values of β-lactam antibiotics such as amoxycillin and cephaloridine against a wide range of resistant organisms. © 1990, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.

引用

页码：70 / 75

页数：6

共 8 条

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