LACK OF EFFECT OF COTRIMOXAZOLE ON THE PHARMACOKINETICS AND PHARMACODYNAMICS OF NIFEDIPINE

被引：2

作者：

EDWARDS, C ^{[1
]}

MONKMAN, S ^{[1
]}

CHOLERTON, S ^{[1
]}

RAWLINS, MD ^{[1
]}

IDLE, JR ^{[1
]}

FERNER, RE ^{[1
]}

机构：

[1] UNIV NEWCASTLE UPON TYNE,DEPT PHARMACOL SCI,NEWCASTLE TYNE NE1 7RU,TYNE & WEAR,ENGLAND

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1990年 / 30卷 / 06期

基金：

英国惠康基金;

关键词：

D O I：

10.1111/j.1365-2125.1990.tb05456.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The pharmacokinetics of nifedipine and its primary oxidised metabolite, M‐I were studied in nine healthy volunteers following a single oral dose of 20 mg nifedipine alone or after pretreatment with oral co‐ trimoxazole. Following pretreatment with co‐trimoxazole, no significant effect was detected on maximum plasma concentration, elimination half‐ life, or area under the plasma concentration‐time curve of either nifedipine or M‐I, nor on the blood pressure response to nifedipine. 1990 The British Pharmacological Society

引用

页码：889 / 891

页数：3

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