SYNTHESIS OF ARENE OXIDE AND TRANS-DIHYDRO DIOL METABOLITES OF ISOQUINOLINE

被引：9

作者：

BOYD, DR ^{[1
]}

DAVIES, RJH ^{[1
]}

HAMILTON, L ^{[1
]}

MCCULLOUGH, JJ ^{[1
]}

机构：

[1] QUEENS UNIV BELFAST,SCH BIOL & BIOCHEM,BELFAST BT9 5AG,ANTRIM,NORTH IRELAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1992年 / 01期

关键词：

D O I：

10.1039/p19920000031

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

5,6-Epoxy-5,6-dihydroisoquinoline 9 and 7,8-epoxy-7,8-dihydroisoquinoline 21 were each obtained by multi-step synthetic sequences from 5,6,7,8-tetrahydroisoquinoline 1. The mammalian metabolite, trans-5,6-dihydroisoquinoline-5,6-diol 10 was chemically synthesised by base-catalysed hydration of the isoquinoline arene oxide 9.

引用

页码：31 / 35

页数：5

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