OCCUPATIONAL EXPERIENCE AND MORTALITY AMONG A COHORT OF METAL COMPONENTS MANUFACTURING WORKERS

被引：22

作者：

ACQUAVELLA, J

LEET, T

JOHNSON, G

机构：

[1] Monsanto Company, St Louis, MO, 63167, A2SL

来源：

EPIDEMIOLOGY | 1993年 / 4卷 / 05期

关键词：

COPD; CUTTING OILS; METAL DUSTS; SOLVENTS; LUNG NEOPLASMS; NEOPLASMS; OCCUPATIONAL EXPOSURE; MORTALITY; COHORT STUDY;

D O I：

10.1097/00001648-199309000-00008

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

We extended a previous cohort study of workers at a metal components manufacturing facility, which found elevated rates of lung cancer and unspecified nonmalignant respiratory diseases, by evaluating mortality rates from 1950 to 1987 for 3,630 workers categorized according to potential exposures to metal dusts, cutting oils/fluids, metal fumes, and solvents. Lung cancer rates were elevated for workers with exposure to metal dusts and cutting oils/fluids [standardized mortality ratio (SMR) = 1.8; 95% confidence interval (CI) = 1.2-2.61. We found that elevated mortality was restricted to those workers first exposed during 1950-1959 (SMR = 2.5; 95% CI = 1.6-3.7) and that mortality rates were similar for workers with exposure durations of <2 years, 2-9 years, and greater-than-or-equal-to 10 years, respectively. The elevated mortality for workers with <2 years exposure and the lack of a trend with exposure duration raise the possibilities of either a short-lived occupational carcinogen or an unspecified confounding factor. Mortality rates for stomach or pancreatic cancers-cancers frequently reported to be in excess for metalworking populations-or for nonmalignant respiratory diseases were consistent with expected values for all exposure subgroups.

引用

页码：428 / 434

页数：7

共 21 条

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