A 3-YEAR STABILITY STUDY OF TOLBUTAMIDE SOLID DISPERSIONS AND BETA-CYCLODEXTRIN COMPLEX

被引：13

作者：

KEDZIEREWICZ, F ^{[1
]}

VILLIERAS, F ^{[1
]}

ZINUTTI, C ^{[1
]}

HOFFMAN, M ^{[1
]}

MAINCENT, P ^{[1
]}

机构：

[1] ENSG,ENVIRONM & MINERALURGIE LAB,CNRS,URA 235,F-54501 VANDOEUVRE NANCY,FRANCE

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1995年 / 117卷 / 02期

关键词：

TOLBUTAMIDE; BETA-CYCLODEXTRIN COMPLEX; SOLID DISPERSION; STABILITY;

D O I：

10.1016/0378-5173(94)00378-I

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The aim of this work was to compare the effect of aging on tolbutamide solid dispersions with PEG 6000 and tolbutamide-beta-cyclodextrin inclusion complex stored at three temperatures for 3 years. The effect of aging was displayed by comparing the physicochemical characteristics followed by X-ray diffractometry, infrared spectrophotometry and differential thermal analysis as well as the dissolution profiles of these compounds. The results obtained showed that tolbutamide-PEG 6000 solid dispersions and tolbutamide-beta-cyclodextrin inclusion complex were stable for the 3 years of the study.

引用

页码：247 / 251

页数：5

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