BIS(ACETATO)AMMINEDICHLORO(CYCLOHEXYLAMINE)PLATINUM(IV), AN ORALLY-ACTIVE ANTICANCER DRUG

被引：36

作者：

NEIDLE, S ^{[1
]}

SNOOK, CF ^{[1
]}

MURRER, BA ^{[1
]}

BARNARD, CFJ ^{[1
]}

机构：

[1] JOHNSON MATTHEY TECHNOL CTR,READING RG4 9NH,BERKS,ENGLAND

来源：

ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS | 1995年 / 51卷

关键词：

D O I：

10.1107/S0108270194013600

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The structure of the anticancer drug bis(acetato)-amminedichloro(cyclohexylamine)platinum(IV), [PtCl2-(C2H3O2)(2)(C6H13N)(NH3)], is reported. The acetato groups are axial to the square plane composed of the chlorine and amine substituents. The cyclohexane ring may sterically hinder one of the acetato groups for metabolic attack. The amine groups are hydrogen bonded to the carbonyl O atoms of the acetato groups.

引用

页码：822 / 824

页数：3

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