SYNTHESIS OF (+)-BIOTIN - EFFICIENT RESOLUTION OF KEY INTERMEDIATES

被引：13

作者：

BIHOVSKY, R ^{[1
]}

BODEPUDI, V ^{[1
]}

机构：

[1] SUNY STONY BROOK,DEPT CHEM,STONY BROOK,NY 11794

来源：

TETRAHEDRON | 1990年 / 46卷 / 23期

关键词：

D O I：

10.1016/S0040-4020(01)90062-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enantiomerically pure 4-chlorothieno[3,4-d]imidazol-2-one (+)-2 and thieno[3,4-d]imidazol-2,4-dione (+)-5, key intermediates in independent routes to (+)-biotin (6), have been prepared by resolution via the corresponding diastereomeric ethers (3d-g and 3'd-g). Efficient procedures to recycle the undesired diastereomers and recover the chiral auxiliary have been developed. © 1990.

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页码：7667 / 7676

页数：10

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