A CONVENIENT SYNTHESIS OF HINDERED AMINES AND ALPHA-TRIFLUOROMETHYLAMINES FROM KETONES

被引：76

作者：

BARNEY, CL ^{[1
]}

HUBER, EW ^{[1
]}

MCCARTHY, JR ^{[1
]}

机构：

[1] MERRELL DOW PHARMACEUT INC,2110 E GALBRAITH RD,CINCINNATI,OH 45215

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 39期

关键词：

D O I：

10.1016/S0040-4039(00)97893-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ketones and α-trifluoromethylketones were converted to primary, secondary, and tertiary amines in good to excellent yields by a reductive amination procedure utilizing TiCl4/NaCNBH3. The method provides the first direct route to α-trifluoromethylamines from ketones, and access to hindered amines from ketones which are unobtainable by Borch reducttve amination. © 1990.

引用

页码：5547 / 5550

页数：4

共 15 条

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