CHATANCIN, A PAF ANTAGONIST FROM A SOFT CORAL, SARCOPHYTON SP

被引:32
作者
SUGANO, M
SHINDO, T
SATO, A
IIJIMA, Y
OSHIMA, T
KUWANO, H
HATA, T
机构
[1] SANKYO CO LTD, NEW LEAD RES LABS, 2-58 1 CHOME HIROMACHI, SHINAGAWA KU, TOKYO 140, JAPAN
[2] SANKYO CO LTD, BIOL RES LABS, TOKYO 140, JAPAN
[3] SANKYO CO LTD, ANALYT & METAB RES LABS, TOKYO 140, JAPAN
关键词
D O I
10.1021/jo00310a001
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
: A PAF antagonist, chatancin, was isolated from a soft coral, Sarcophyton sp. Its structure (la) was determined to be (IR,2S,4aR,4bR,7S,8aS,10aR)-4a,7-dimethyl-1,8a-epoxy-1 -hydroxy- 2- isopropyl-10- (methoxy-carbonyl)-l,2,3,4,4a,4b,5,6,7,8,8a,10a-dodecahydro- phenanthrene on the basis of chemical and physical evidences and X-ray crystallographic analysis. © 1990, American Chemical Society. All rights reserved.
引用
收藏
页码:5803 / 5805
页数:3
相关论文
共 11 条
[1]   STUDIES OF AUSTRALIAN SOFT CORALS .46. NEW DITERPENES FROM A BRIAREUM SPECIES (ANTHOZOA, OCTOCORALLIA, GORGONACEA) [J].
BOWDEN, BF ;
COLL, JC ;
VASILESCU, IM .
AUSTRALIAN JOURNAL OF CHEMISTRY, 1989, 42 (10) :1705-1726
[2]  
BRAQUET P, 1987, PHARMACOL REV, V39, P97
[3]  
COOPER K, 1989, ANNU REP MED CHEM, V24, P81
[4]  
CORDEIRO RSB, 1989, DN P, V2, P287
[5]  
FAULKNER DJ, 1989, NAT PROD REP, V42, P1705
[6]   DITERPENOIDS [J].
HANSON, JR .
NATURAL PRODUCT REPORTS, 1986, 3 (04) :307-322
[7]   ANTAGONISTS OF PLATELET ACTIVATING FACTOR FROM SWIETENIA-MAHOGANI (L) JACQ [J].
KADOTA, S ;
MARPAUNG, L ;
KIKUCHI, T ;
EKIMOTO, H .
TETRAHEDRON LETTERS, 1989, 30 (09) :1111-1114
[8]  
Krebs H C, 1986, Fortschr Chem Org Naturst, V49, P151
[9]  
OKAMOTO M, 1986, CHEM PHARM BULL, V34, P340
[10]   STRUCTURE OF FR900452, A NOVEL PLATELET-ACTIVATING-FACTOR INHIBITOR FROM A STREPTOMYCES [J].
TAKASE, S ;
SHIGEMATSU, N ;
SHIMA, I ;
UCHIDA, I ;
HASHIMOTO, M ;
TADA, T ;
KODA, S ;
MORIMOTO, Y .
JOURNAL OF ORGANIC CHEMISTRY, 1987, 52 (15) :3485-3487