CALCITONIN GENE-RELATED PEPTIDE PROMOTES TRANSIENT RADIOCALCIUM UPTAKE INTO CHICK BONE INVIVO

被引：17

作者：

ANCILL, AK ^{[1
]}

BASCAL, ZA ^{[1
]}

WHITAKER, G ^{[1
]}

DACKE, CG ^{[1
]}

机构：

[1] PORTSMOUTH POLYTECH,SCH PHARM & BIOMED SCI,DIV PHARMACOL,WHITE SWAN RD,PORTSMOUTH PO1 2DT,ENGLAND

来源：

EXPERIMENTAL PHYSIOLOGY | 1991年 / 76卷 / 01期

关键词：

D O I：

10.1113/expphysiol.1991.sp003477

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

We have examined the in vivo effects in chicks of intravenously injected chicken (c-) and rat (r-) calcitonin gene-related peptides (CGRP) on uptake into bone of a simultaneously administered Ca-45 label. Both peptides caused transient (10 min) increases in Ca-45 uptake into a variety of bone types. In dose-response experiments at 10 min, CGRP doses of 0.26-1.04 nmol/100 g body wt were found to give maximal responses. These were well developed in chicks fasted for 22 h but absent in those which were continuously fed. This contrasts with the hypercalcaemic effect of CGRP which is apparent in fed rather than fasted chicks.

引用

页码：143 / 146

页数：4

共 9 条

[1] EFFECTS OF RAT AND CHICKEN CALCITONIN GENE-RELATED PEPTIDES (CGRP) UPON CALCIUM-METABOLISM IN CHICKS [J].