ORNITHINE DECARBOXYLASE AS AN ENZYME TARGET FOR THERAPY

被引：230

作者：

MCCANN, PP

PEGG, AE

机构：

[1] PENN STATE UNIV,MILTON S HERSHEY MED CTR,COLL MED,MILTON S HERSHEY MED CTR,HERSHEY,PA 17033

[2] PENN STATE UNIV,MILTON S HERSHEY MED CTR,COLL MED,MILTON S HERSHEY MED CTR,DEPT PHARMACOL,HERSHEY,PA 17033

来源：

PHARMACOLOGY & THERAPEUTICS | 1992年 / 54卷 / 02期

关键词：

D O I：

10.1016/0163-7258(92)90032-U

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

Interest in ornithine decarboxylase (ODC) and the therapeutic effects of its inhibition with the consequent depletion of polyamine biosynthesis has been widespread since the late 1970s and 1980s. This review covers new information about the properties of ODC, recent findings with ODC inhibitors and a discussion of the mechanism of inactivation of ODC by eflornithine. Recent in vivo therapeutic approaches of ODC inhibition are also discussed including: cancer and cancer chemoprevention; autoimmune diseases; polyamines and the blood-brain barrier, ischemia and hyperplasia; the NMDA receptor and modulation by polyamines; hearing loss; African trypanosomiasis; Pneumocystis carinii pneumonia and Cryptosporidium in AIDS; and other infectious diseases/organisms.

引用

页码：195 / 215

页数：21

共 130 条

[1]

EVALUATION OF CONTINUOUS-INFUSION ALPHA-DIFLUOROMETHYLORNITHINE THERAPY FOR COLORECTAL-CARCINOMA [J].

AJANI, JA ;

OTA, DM ;

GROSSIE, VB ;

ABBRUZZESE, JL ;

FAINTUCH, JS ;

PATT, YZ ;

JACKSON, DE ;

LEVIN, B ;

NISHIOKA, K .

CANCER CHEMOTHERAPY AND PHARMACOLOGY, 1990, 26 (03) :223-226

[2]

AJANI JA, 1989, CANCER RES, V49, P5761

[3]

STUDY OF POSTNATAL EFFECTS OF CHEMOPREVENTIVE AGENTS ON OFFSPRING OF ETHYLNITROSOUREA-INDUCED TRANSPLACENTAL CARCINOGENESIS IN RATS .1. INFLUENCE OF RETINOL ACETATE, ALPHA-TOCOPHEROL ACETATE, THIAMINE CHLORIDE, SODIUM SELENITE, AND ALPHA-DIFLUOROMETHYLORNITHINE [J].

ALEXANDROV, VA ;

BESPALOV, VG ;

BOONE, CW ;

KELLOFF, GJ ;

MALONE, WF .

CANCER LETTERS, 1991, 60 (02) :177-184

[4]

Bacchi C.J., 1987, P317

[5]

Bachrach U, 1989, PHYSL POLYAMINES

[6]

BARROSO L, 1990, ANAL SEQUENCE SPEC O

[7]

BASSEZ T, 1990, DEVELOPMENT, V110, P955

[8]

BERGER FG, 1989, BIOCHEM GENET, V27, P745, DOI 10.1007/BF02396065

[9]

Bey P., 1987, INHIBITION POLYAMINE, P1

[10]

CATALYTIC IRREVERSIBLE INHIBITION OF TRYPANOSOMA-BRUCEI-BRUCEI ORNITHINE DECARBOXYLASE BY SUBSTRATE AND PRODUCT ANALOGS AND THEIR EFFECTS ON MURINE TRYPANOSOMIASIS [J].

BITONTI, AJ ;

BACCHI, CJ ;

MCCANN, PP ;

SJOERDSMA, A .

BIOCHEMICAL PHARMACOLOGY, 1985, 34 (10) :1773-1777

← 1 2 3 4 5 6 7 8 9 10 →