MOLECULAR-CLONING OF A MURINE N-TYPE CALCIUM-CHANNEL ALPHA-1 SUBUNIT - EVIDENCE FOR ISOFORMS, BRAIN DISTRIBUTION, AND CHROMOSOMAL LOCALIZATION

被引：38

作者：

COPPOLA, T

WALDMANN, R

BORSOTTO, M

HEURTEAUX, C

ROMEY, G

MATTEI, MG

LAZDUNSKI, R

机构：

[1] INST PHARMACOL MOLEC & CELLULAIRE,F-06560 VALBONNE,FRANCE

[2] HOP ENFANTS LA TIMONE,CTR GENET MED,INSERM,U242,F-13385 MARSEILLE 05,FRANCE

来源：

FEBS LETTERS | 1994年 / 338卷 / 01期

关键词：

CALCIUM CHANNEL; BRAIN; ISOFORM; MURINE CHROMOSOMAL LOCALIZATION;

D O I：

10.1016/0014-5793(94)80105-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A cDNA encoding a N-type Ca2+ channel has been cloned from the murine neuroblastoma cell line N1A103. The open reading frame encodes a protein of 2,289 amino acids (257 kDa). Analysis of different clones provided evidence for the existence of distinct isoforms of N-type channels. High levels of mRNA were found in the pyramidal cell layers CA1, CA2 and CA3 of the hippocampus, in the dentate gyrus, in the cortex layers 2 and 4, in the subiculum and the habenula. The N-type Ca2+ channel gene has been localized on the chromosome 2, band A.

引用

页码：1 / 5

页数：5

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