Diabetic nephropathy - complications and treatment

被引:464
作者
Lim, Andy K. H. [1 ,2 ,3 ]
机构
[1] Monash Hlth, Monash Med Ctr, Dept Nephrol, 246 Clayton Rd, Clayton, Vic 3168, Australia
[2] Dandenong Hosp, Monash Hlth, Dept Gen Med, Melbourne, Vic 3168, Australia
[3] Monash Univ, Dept Med, Clayton, Vic, Australia
关键词
diabetes; diabetic nephropathy; albuminuria; kidney disease; inflammation;
D O I
10.2147/IJNRD.S40172
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 [临床医学]; 100201 [内科学];
摘要
Diabetic nephropathy is a significant cause of chronic kidney disease and end-stage renal failure globally. Much research has been conducted in both basic science and clinical therapeutics, which has enhanced understanding of the pathophysiology of diabetic nephropathy and expanded the potential therapies available. This review will examine the current concepts of diabetic nephropathy management in the context of some of the basic science and pathophysiology aspects relevant to the approaches taken in novel, investigative treatment strategies.
引用
收藏
页码:361 / 381
页数:21
相关论文
共 234 条
[1]
Abe M, 2011, J ATHEROSCLER THROMB, V18, P1018
[2]
Abnormal p38 mitogen-activated protein kinase signalling in human and experimental diabetic nephropathy [J].
Adhikary, L ;
Chow, F ;
Nikolic-Paterson, DJ ;
Stambe, C ;
Dowling, J ;
Atkins, RC ;
Tesch, GH .
DIABETOLOGIA, 2004, 47 (07) :1210-1222
[3]
Standards of Medical Care in Diabetes-2014 [J].
不详 .
DIABETES CARE, 2014, 37 :S14-S80
[4]
Anderson JW, 2008, ASIA PAC J CLIN NUTR, V17, P324
[5]
Predictive Effects of Urinary Liver-Type Fatty Acid-Binding Protein for Deteriorating Renal Function and Incidence of Cardiovascular Disease in Type 2 Diabetic Patients Without Advanced Nephropathy [J].
Araki, Shin-ichi ;
Haneda, Masakazu ;
Koya, Daisuke ;
Sugaya, Takeshi ;
Isshiki, Keiji ;
Kume, Shinji ;
Kashiwagi, Atsunori ;
Uzu, Takashi ;
Maegawa, Hiroshi .
DIABETES CARE, 2013, 36 (05) :1248-1253
[6]
Urinary MicroRNA Profiling in the Nephropathy of Type 1 Diabetes [J].
Argyropoulos, Christos ;
Wang, Kai ;
McClarty, Sara ;
Huang, David ;
Bernardo, Jose ;
Ellis, Demetrius ;
Orchard, Trevor ;
Galas, David ;
Johnson, John .
PLOS ONE, 2013, 8 (01)
[7]
The role of bone marrow derived-mesenchymal stem cells in attenuation of kidney function in rats with diabetic nephropathy [J].
Aziz, Mohamed Talaat Abdel ;
Wassef, Mohamed Abdel Aziz ;
Ahmed, Hanan Hosni ;
Rashed, Laila ;
Mahfouz, Soheir ;
Aly, Mayssa Ibrahim ;
Hussein, Rania Elsayed ;
Abdelaziz, Mai .
DIABETOLOGY & METABOLIC SYNDROME, 2014, 6
[8]
Rosiglitazone reduces microalbuminuria and blood pressure independently of glycemia in type 2 diabetes patients with microalbuminuria [J].
Bakris, George L. ;
Ruilope, Luis M. ;
McMorn, Stephen O. ;
Weston, Wayde M. ;
Heise, Mark A. ;
Freed, Martin I. ;
Porter, Lisa E. .
JOURNAL OF HYPERTENSION, 2006, 24 (10) :2047-2055
[9]
Effects of an ACE inhibitor calcium antagonist combination on proteinuria in diabetic nephropathy [J].
Bakris, GL ;
Weir, MR ;
DeQuattro, V ;
McMahon, FG .
KIDNEY INTERNATIONAL, 1998, 54 (04) :1283-1289
[10]
Calcium channel blockers versus other antihypertensive therapies on progression of NIDDM associated nephropathy [J].
Bakris, GL ;
Copley, JB ;
Vicknair, N ;
Sadler, R ;
Leurgans, S .
KIDNEY INTERNATIONAL, 1996, 50 (05) :1641-1650