CHANGES IN PROTEOGLYCAN BIOSYNTHESIS FOLLOWING LEUKOCYTE ELASTASE TREATMENT OF BOVINE ARTICULAR-CARTILAGE IN CULTURE

被引：35

作者：

BARTHOLOMEW, JS ^{[1
]}

LOWTHER, DA ^{[1
]}

HANDLEY, CJ ^{[1
]}

机构：

[1] MONASH UNIV, DEPT BIOCHEM, CLAYTON, VIC 3168, AUSTRALIA

来源：

ARTHRITIS AND RHEUMATISM | 1984年 / 27卷 / 08期

关键词：

D O I：

10.1002/art.1780270810

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Treatment of bovine articular cartilage in culture with a low MW elastase purified from rabbit polymorphonuclear leukocytes resulted in degradation and release of proteoglycans from the tissue, coupled with a prolonged inhibition of proteoglycan biosynthesis. These observations are consistent with those seen in experimental arthritis induced in rabbits. Comparison of the size of the proteoglycan degradation products extracted from elastase-treated cartilage in culture with that from arthritic cartilage showed marked similarities. Leukocyte elastase is a contributing factor in proteoglycan degradation and inhibition of synthesis in inflammatory joint disease.

引用

页码：905 / 912

页数：8

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