MORPHINE PRODUCES RELEASE OF SUBSTANCE-P-LIKE IMMUNOREACTIVITY FROM GUINEA-PIG CENTRAL-NERVOUS-SYSTEM

被引：9

作者：

CHAHL, LA

机构：

[1] Neuropharmacology Laboratory, Faculty of Medicine, University of Newcastle, Newcastle, NSW

来源：

NEUROSCIENCE LETTERS | 1990年 / 118卷 / 01期

基金：

英国医学研究理事会;

关键词：

Central nervous system; Dependence; Guinea-pig ileum; Morphine; Naloxone; Opioid; Substance P;

D O I：

10.1016/0304-3940(90)90255-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent evidence suggests that opioids might have excitatory as well as inhibitory actions on neurones. Since substance P (SP) has been implicated in opioid withdrawal, the present experiment was conducted to determine whether SP was released by morphine or morphine withdrawal. Sagittal brain slices and a 2 cm piece of ileum from 5 guinea-pigs were placed in Krebs solution. Morphine 1 μM, produced significant release of SP-like immunoreactivity (SP-LI) within 2 min from brain slices but release from ileum preparations was variable. Naloxone 1 μM, added 5 min after morphine, did not produce significantly greater increase in concentration of SP-LI. It is concluded that morphine releases SP from guinea-pig brain slices. © 1990.

引用

页码：88 / 90

页数：3

共 20 条

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