HYPOTHALAMIC-PITUITARY-ADRENAL AXIS DYSREGULATION AMONG DIABETIC OUTPATIENTS

被引：99

作者：

ROY, M

COLLIER, B

ROY, A

机构：

[1] NEI,BETHESDA,MD 20205

[2] NIAAA,BETHESDA,MD

来源：

PSYCHIATRY RESEARCH | 1990年 / 31卷 / 01期

关键词：

adrenocorticotropic hormone; cortisol; dexamethasone suppression test; diabetes; Hypothalamic-pituitary-adrenal axis;

D O I：

10.1016/0165-1781(90)90106-F

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

We compared insulin-requiring diabetic outpatients (n = 49) with normal controls (n = 42) for indices of hypothalamic-pituitary-adrenal (HPA) axis activity. Diabetic patients showed significantly elevated 9 a.m. plasma levels of cortisol as well as significantly elevated plasma levels of cortisol and adrenocorticotropic hormone (ACTH) at both 4 p.m. before and 4 p.m. after dexamethasone. Also, there was a significant correlation between postdexamethasone plasma levels of ACTH and duration of diabetes. These results suggest that HPA-axis dysregulation is found among diabetic outpatients. The possible psychiatric implications are discussed. © 1990.

引用

页码：31 / 37

页数：7

共 26 条

[1] AN INVENTORY FOR MEASURING DEPRESSION [J].