UNIQUE SEQUENCES IN THE ENV GENE OF AVIAN HEMANGIOMA RETROVIRUS ARE RESPONSIBLE FOR CYTOTOXICITY AND ENDOTHELIAL-CELL PERTURBATION

被引：13

作者：

BURSTEIN, H

RESNICKROGUEL, N

HAMBURGER, J

ARAD, G

MALKINSON, M

KOTLER, M

机构：

[1] HEBREW UNIV JERUSALEM,HADASSAH MED SCH,DEPT MOLEC GENET,POB 1172,IL-91010 JERUSALEM,ISRAEL

[2] KIMRON VET INST,DEPT POULTRY DIS,BET DAGAN,ISRAEL

来源：

VIROLOGY | 1990年 / 179卷 / 01期

关键词：

D O I：

10.1016/0042-6822(90)90327-N

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

An avian retrovirus isolated from spontaneous cavernous hemangiomas of layer hens codes for an env protein that induces a cytopathic effect on a wide variety of cultured avian and mammalian cells and also causes thrombogenicity of endothelial cells. Sequence analysis of the avian hemangioma inducing virus revealed unique elements in both its env gene and its LTR. We propose that these elements are responsible for the biological and pathogenic characteristics of the virus. © 1990.

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页码：512 / 516

页数：5

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