A PROTEIN REQUIRED FOR SECRETION OF CHOLERA-TOXIN THROUGH THE OUTER-MEMBRANE OF VIBRIO-CHOLERAE

被引：67

作者：

SANDKVIST, M

MORALES, V

BAGDASARIAN, M

机构：

[1] MICHIGAN STATE UNIV, DEPT MICROBIOL, S110 PLANT BIOL BLDG, E LANSING, MI 48824 USA

[2] UMEA UNIV, APPL CELL & MOLEC BIOL UNIT, S-90187 UMEA, SWEDEN

来源：

GENE | 1993年 / 123卷 / 01期

关键词：

EXTRACELLULAR SECRETION; SECRETION GENES; RECOMBINANT DNA; ENTEROTOXIN;

D O I：

10.1016/0378-1119(93)90543-C

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A gene essential for the secretion of cholera toxin from the periplasm of Vibrio cholerae into the extracellular medium has been isolated and its nucleotide sequence determined. It encodes a cytoplasmic protein of 56 kDa that exhibits a high degree of similarity to gene products required for extracellular protein secretion in several other Gram - organisms. Sequence similarities in its potential ATP-binding site suggest that the protein may act as an energy provider or signal transducer in the process of extracellular secretion.

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页码：81 / 86

页数：6

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