ROLE OF ENDOGENOUS PLATELET-ACTIVATING-FACTOR IN CERULEIN-INDUCED ACUTE-PANCREATITIS IN RATS - PROTECTIVE EFFECTS OF A PAF-ANTAGONIST

被引：21

作者：

FUJIMURA, K ^{[1
]}

KUBOTA, Y ^{[1
]}

OGURA, M ^{[1
]}

YAMAGUCHI, T ^{[1
]}

BINNAKA, T ^{[1
]}

TANI, K ^{[1
]}

KITAGAWA, S ^{[1
]}

MIZUNO, T ^{[1
]}

INOUE, K ^{[1
]}

机构：

[1] KANSAI MED UNIV,DEPT INTERNAL MED 3,1 FUMIZONO CHO,MORIGUCHI,OSAKA 570,JAPAN

来源：

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | 1992年 / 7卷 / 02期

关键词：

ACUTE PANCREATITIS; CERULEIN (CR); PLATELET-ACTIVATING FACTOR (PAF);

D O I：

10.1111/j.1440-1746.1992.tb00962.x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The role of endogenous platelet-activating factor (PAF) in the pathogenesis of acute pancreatitis was investigated by determining whether CV-6209, a selective PAF antagonist, confers protection against caerulein-induced acute pancreatitis in rats. Continuous intravenous infusion of caerulein (5-mu-g/kg x h) induced time-dependent increase in serum pancreatic enzymes, pancreatic weight, and protein content of the pancreas, and produced histologic evidence of acute pancreatitis. Pretreatment with CV-6209 (1 mg/kg) significantly inhibited the elevation of serum pancreatic enzymes, pancreatic weight, and protein content of the pancreas. Caerulein-induced tissue oedema and recruitment of leucocytic cells were markedly ameliorated with CV-6209. Platelet-activating factor may be released endogenously and may play a role during acute pancreatitis.

引用

页码：199 / 202

页数：4

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