CONVENIENT SYNTHESIS OF 4-AMINO-7-(DIALKYLAMINO)PYRIDO[2,3-D]PYRIMIDINES FROM POLYSUBSTITUTED PYRIDINES

被引:11
作者
COCCO, MT
CONGIU, C
MACCIONI, A
ONNIS, V
机构
[1] Dipartimento Farmaco Chimico Tecnologico, Università, Cagliari, I-09124
关键词
D O I
10.1002/jhet.5570300143
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A convenient synthesis of 4-amino-7-(dialkylamino)pyrido[2,3-d]pyrimidines via cyclization of functionalized pyridines is reported. The preparation of the starting pyridines from 3-amino-3-(dialkylamino)propene-nitriles and ethoxymethylenemalononitrile is described.
引用
收藏
页码:253 / 256
页数:4
相关论文
共 9 条
[1]  
COCCO MT, 1989, J HETEROCYCLIC CHEM, V26, P1859
[2]   SYNTHESIS OF PYRIDINES BY HETEROCYCLIZATION OF NEW DIENAMINO ESTERS [J].
COCCO, MT ;
CONGIU, C ;
MACCIONI, A .
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1990, 27 (04) :1143-1151
[3]  
COCCO MT, 1991, SYNTHESIS-STUTTGART, P529
[4]  
COCCO MT, 1992, SYNTHESIS-STUTTGART, P371
[5]  
COCCO MT, 1987, FARMACO, V42, P347
[6]   SYNTHESIS AND ANTI-TUMOR ACTIVITY OF 2,4-DIAMINO-6-(2,5-DIMETHOXYBENZYL)-5-METHYLPYRIDO[2,3-D]PYRIMIDINE [J].
GRIVSKY, EM ;
LEE, S ;
SIGEL, CW ;
DUCH, DS ;
NICHOL, CA .
JOURNAL OF MEDICINAL CHEMISTRY, 1980, 23 (03) :327-329
[7]   STUDIES ON CONDENSED PYRIMIDINE SYSTEMS .25. 2,4-DIAMINOPYRIDO[2,3-D]PYRIMIDINES . BIOLOGICAL DATA [J].
HURLBERT, BS ;
FERONE, R ;
HERRMANN, TA ;
HITCHING.GH ;
BARNETT, M ;
BUSHBY, SRM .
JOURNAL OF MEDICINAL CHEMISTRY, 1968, 11 (04) :711-&
[8]  
KRETZSCHMAR E, 1980, PHARMAZIE, V35, P253
[9]  
SUZUKI N, 1980, CHEM PHARM BULL, V28, P761