MEASUREMENT OF LOW-MOLECULAR-WEIGHT ANTIOXIDANTS, URIC-ACID, TYROSINE AND TRYPTOPHAN IN PLAQUES AND WHITE MATTER FROM PATIENTS WITH MULTIPLE-SCLEROSIS

被引：75

作者：

LANGEMANN, H ^{[1
]}

KABIERSCH, A ^{[1
]}

NEWCOMBE, J ^{[1
]}

机构：

[1] INST NEUROL,DEPT NEUROCHEM,MULTIPLE SCLEROSIS SOC LAB,LONDON WC1N 3BG,ENGLAND

来源：

EUROPEAN NEUROLOGY | 1992年 / 32卷 / 05期

关键词：

MULTIPLE SCLEROSIS; PLAQUES; ANTIOXIDANTS; AMINO ACIDS; URIC ACID; DNA; CHOLESTEROL;

D O I：

10.1159/000116835

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The levels of the antioxidants ascorbic acid, cysteine, reduced glutathione and alpha-tocopherol, of the free-radical marker uric acid and of the amino acids tyrosine and tryptophan were measured by means of high-pressure liquid chromatography in plaques, adjacent white matter and distant white matter from patients with multiple sclerosis, and in central nervous system tissue from patients without neurological diseases. Cholesterol and DNA were also determined, to check demyelination and cellularity. Uric acid was increased and glutathione correspondingly decreased in plaques; alpha-tocopherol was lowest in plaques and highest in distant white matter in all cases. Ascorbic acid, cysteine, tyrosine and tryptophan were not significantly changed in any tissue. The results provide evidence supporting the involvement of free radicals in multiple sclerosis.

引用

页码：248 / 252

页数：5

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