EFFECTS OF ALTERING PALMITYLATION SITES ON BIOSYNTHESIS AND FUNCTION OF THE INFLUENZA-VIRUS HEMAGGLUTININ

被引：52

作者：

NAIM, HY ^{[1
]}

AMARNEH, B ^{[1
]}

KTISTAKIS, NT ^{[1
]}

ROTH, MG ^{[1
]}

机构：

[1] UNIV TEXAS,SW MED CTR,DEPT BIOCHEM,5323 HARRY HINES BLVD,DALLAS,TX 75235

来源：

JOURNAL OF VIROLOGY | 1992年 / 66卷 / 12期

关键词：

D O I：

10.1128/JVI.66.12.7585-7588.1992

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Mutagenesis studies indicated that the three cytoplasmic cysteines of the influenza virus A/Japan/305/57 hemagglutinin (HA) are all palmitylated, but to an unequal extent. Replacement of all three cysteines abolished palmitylation, but affected neither HA biosynthesis nor function. Palmitate was not required for HA to be incorporated into virions.

引用

页码：7585 / 7588

页数：4

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