RADIOTHERAPY OF PROSTATE-CANCER - ESTABLISHED RESULTS AND NEW DEVELOPMENTS

被引：12

作者：

DEARNALEY, DP

机构：

[1] Academic Unit of Radiotherapy and Oncology, the Royal Marsden Hospital and Institute of Cancer Research, Button, Surrey

来源：

SEMINARS IN SURGICAL ONCOLOGY | 1995年 / 11卷 / 01期

关键词：

CONFORMAL TREATMENT; NEOADJUVANT AND ADJUVANT HORMONE TREATMENT; PARTICLE BEAM THERAPY; RADIOTHERAPY COMPLICATIONS;

D O I：

10.1002/ssu.2980110108

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Radical radiotherapy has been established as an effective modality for eradicating localised prostate cancer. No satisfactory comparisons have been made with patients treated by total prostatectomy, but in surgically staged patients with negative lymph nodes survival after radiotherapy exceeds that of an aged matched population, cancer deaths occurring in only 6-15% of patients and 85% remaining free of local recurrence after 10 years. Results are predictably less satisfactory in surgically unstaged cases and for more advanced localised presentations. Nevertheless, radical radiotherapy achieves local control of disease in the majority of patients. Improved local control may be obtained by increasing radiation dose but at the expense of increased radiation-induced side-effects. Conformal radiotherapy and combined modality treatment with the neoadjuvant or adjuvant androgen deprivation show considerable promise as novel methods to improve the therapeutic ratio, and prospective randomised studies are underway to test these approaches. (C) 1995 Wiley-Liss, Inc.

引用

页码：50 / 59

页数：10

共 73 条

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