INHIBITION OF PHENYLETHANOLAMINE N-METHYLTRANSFERASE (PNMT) BY AROMATIC HYDROXY-SUBSTITUTED 1,2,3,4-TETRAHYDROISOQUINOLINES - FURTHER-STUDIES ON THE HYDROPHILIC POCKET OF THE AROMATIC RING BINDING REGION OF THE ACTIVE-SITE

被引：39

作者：

SALL, DJ ^{[1
]}

GRUNEWALD, GL ^{[1
]}

机构：

[1] UNIV KANSAS, DEPT MED CHEM, LAWRENCE, KS 66045 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1987年 / 30卷 / 12期

关键词：

D O I：

10.1021/jm00395a006

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：2208 / 2216

页数：9

共 50 条

[1]

AXELROD J, 1962, J BIOL CHEM, V237, P1657

[2] ACUTE CARDIOVASCULAR EFFECTS OF 2 CENTRAL PHENYLETHANOLAMINE-N-METHYL-TRANSFERASE INHIBITORS IN UNANESTHETIZED DESOXYCORTICOSTERONE-SALT HYPERTENSIVE RATS [J].

BIOLLAZ, B ;

BIOLLAZ, J ;

KOHLMAN, O ;

BRESNAHAN, M ;

GAVRAS, I ;

GAVRAS, H .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1984, 102 (3-4) :515-519

[3] INHIBITORS OF PHENYLETHANOLAMINE N-METHYLTRANSFERASE AND EPINEPHRINE BIOSYNTHESIS .2. 1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONANILIDES [J].

BLANK, B ;

KROG, AJ ;

WEINER, G ;

PENDLETON, RG .

JOURNAL OF MEDICINAL CHEMISTRY, 1980, 23 (08) :837-840

[4] SYNTHESIS OF ISOQUINOLINES .3. A NEW SYNTHESIS OF 1,2,3,4-TETRAHYDROISOQUINOLINES [J].

BOBBITT, JM ;

KIELY, JMN ;

KHANNA, KL ;

EBERMANN, R .

JOURNAL OF ORGANIC CHEMISTRY, 1965, 30 (07) :2247-+

[5] INHIBITORS OF PHENYLETHANOLAMINE N-METHYLTRANSFERASE AND EPINEPHRINE BIOSYNTHESIS .1. CHLORO-SUBSTITUTED 1,2,3,4-TETRAHYDROISOQUINOLINES [J].

BONDINELL, WE ;

CHAPIN, FW ;

GIRARD, GR ;

KAISER, C ;

KROG, AJ ;

PAVLOFF, AM ;

SCHWARTZ, MS ;

SILVESTRI, JS ;

VAIDYA, PD ;

LAM, BL ;

WELLMAN, GR ;

PENDLETON, RG .

JOURNAL OF MEDICINAL CHEMISTRY, 1980, 23 (05) :506-511

[6] INHIBITORS OF PHENYLETHANOLAMINE N-METHYLTRANSFERASE AND EPINEPHRINE BIOSYNTHESIS - A POTENTIAL SOURCE OF NEW DRUGS [J].

BONDINELL, WE ;

CHAPIN, FW ;

FRAZEE, JS ;

GIRARD, GR ;

HOLDEN, KG ;

KAISER, C ;

MARYANOFF, C ;

PERCHONOCK, CD ;

GESSNER, GW ;

HIEBLE, JP ;

HILLEGASS, LM ;

PENDLETON, RG ;

SAWYER, JL .

DRUG METABOLISM REVIEWS, 1983, 14 (04) :709-721

[7]

BORGES JMD, 1978, NEUROCHEM RES, V3, P15

[8] ENZYMATIC SYNTHESIS OF ADRENALINE IN MAMMALIAN BRAIN [J].

CIARANELLO, RD ;

BARCHAS, RE ;

BYERS, GS ;

STEMMLE, DW ;

BARCHAS, JD .

NATURE, 1969, 221 (5178) :368-+

[9]

CONNETT RJ, 1970, J BIOL CHEM, V245, P329

[10] EFFECTS OF AN EPINEPHRINE SYNTHESIS INHIBITOR, SKF64139, ON THE SECRETION OF LUTEINIZING-HORMONE IN OVARIECTOMIZED FEMALE RATS [J].

CROWLEY, WR ;

TERRY, LC .

BRAIN RESEARCH, 1981, 204 (01) :231-235

← 1 2 3 4 5 →