THE GABA-WITHDRAWAL SYNDROME - A NEW MODEL OF FOCAL EPILEPTOGENESIS

被引:60
作者
BRAILOWSKY, S [1 ]
KUNIMOTO, M [1 ]
MENINI, C [1 ]
SILVABARRAT, C [1 ]
RICHE, D [1 ]
NAQUET, R [1 ]
机构
[1] CNRS, PHYSIOL NERVEUSE LAB 1, F-91190 GIF SUR YVETTE, FRANCE
关键词
D O I
10.1016/0006-8993(88)91448-5
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
A novel model of focal, cortical epilepsy is described. Chronic (6 h to 14 days), localized application of .gamma.-aminobutyric acid (GABA) into the somatomotor cortex of rats induces, upon withdrawal, the appearance of epileptogenic activity with maximal electrographic expression circumscribed to the infused site. This GABA-withdrawal syndrome (tested for a 100 .mu.g/.mu.l/h dose) lasted from 24 to 168 h (mean values). A significant correlation was found between infusion time and duration of the excitability rebound, with the longer duration corresponding to the shorter infusion time. A distant lesion effect was observed in the thalamic area of cortical projection. The potential use of this neurotransmitter-induced phenomenon in the study of brain plasticity in general, and of epilepsy in particular, is discussed.
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收藏
页码:175 / 179
页数:5
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