IDENTITY BETWEEN THE NOVEL INTEGRIN BETA-7-SUBUNIT AND AN ANTIGEN FOUND HIGHLY EXPRESSED ON INTRAEPITHELIAL LYMPHOCYTES IN THE SMALL-INTESTINE

被引：42

作者：

YUAN, Q ^{[1
]}

JIANG, WM ^{[1
]}

HOLLANDER, D ^{[1
]}

LEUNG, E ^{[1
]}

WATSON, JD ^{[1
]}

KRISSANSEN, GW ^{[1
]}

机构：

[1] UNIV CALIF IRVINE, DEPT MED, IRVINE, CA 92717 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 176卷 / 03期

关键词：

D O I：

10.1016/0006-291X(91)90448-G

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A cDNA clone encoding the N-terminal sequence of the murine integrin β7 subunit, a novel member of the leukocyte cell adhesion molecule subset (Leu-CAM), has been isolated. An N-terminal region of 13 contiguous amino acids deduced from the cDNA shows complete identity with the N-terminus of the 120 kDa subunit of the M290 antigen, a surface molecule found highly expressed on mouse intestinal intraepithelial lymphocytes (IEL). This unexpected result focuses two previously unconnected areas of research and suggests that integrins may have a special role to play in the defence of the gut mucosa. © 1991.

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页码：1443 / 1449

页数：7

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