EFFECTS OF GANGLIOSIDE (CRONASSIAL) TREATMENT ON MHC IA-ANTIGEN EXPRESSION AND ALLOGRAFT SURVIVAL OF PANCREATIC-ISLETS IN DIABETIC RATS

被引：7

作者：

BRETZEL, RG ^{[1
]}

FLESCH, BK ^{[1
]}

WILLIG, J ^{[1
]}

WOEHRLE, M ^{[1
]}

FEDERLIN, K ^{[1
]}

机构：

[1] UNIV GIESSEN,POLYCLIN,W-6300 GIESSEN,GERMANY

来源：

DIABETOLOGIA | 1990年 / 33卷 / 02期

关键词：

Gangliosides; immunomodulation; immunosuppression; islet transplantation;

D O I：

10.1007/BF00401049

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Streptozotocin-diabetic BdII rats were treated daily with 20 mg/kg body weight gangliosides for ten days beginning two days before transplantation. This treatment did not prolong allograft survival of untreated Lewis islets. Culture treatment of isolated Lewis islets with gangliosides (100 μg/ml in RPMI 1640) for one day resulted in a significant reduction of MHC Ia antigen positive cells but not of class I antigens within the islets. Tranplantation of the ganglioside pretreated islets into non-immunosuppressed BdII recipients prolonged allograft survival to 12 days only in one of five animals. © 1990 Springer-Verlag.

引用

页码：112 / 114

页数：3

共 8 条

[1] AN IMPROVED METHOD FOR ISOLATION OF MOUSE PANCREATIC-ISLETS [J].

GOTOH, M ;

MAKI, T ;

KIYOIZUMI, T ;

SATOMI, S ;

MONACO, AP .

TRANSPLANTATION, 1985, 40 (04) :437-438

[2] INHIBITION OF INTERLEUKIN-2-DEPENDENT CYTO-TOXIC LYMPHOCYTE-T GROWTH BY GANGLIOSIDES [J].

MERRITT, WD ;

BAILEY, JM ;

PLUZNIK, DH .

CELLULAR IMMUNOLOGY, 1984, 89 (01) :1-10

[3]

OFFNER H, 1987, J IMMUNOL, V139, P3295

[4]

SAMSON J C, 1986, Drugs of Today, V22, P73

[5]

WHISLER RL, 1980, J IMMUNOL, V125, P2106

[6]

WIEGANDT H, 1985, NEW COMPREHENSIVE BI, V10, P199

[7]

WILBERZ S, 1988, DIABETOLOGIA, V31, P855

[8]

WILBERZ S, 1987, DIABETOLOGIA, V31, P559

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