CHROMOSOME AND SCE ANALYSIS IN PERIPHERAL LYMPHOCYTES OF PERSONS OCCUPATIONALLY EXPOSED TO CYTOSTATIC DRUGS HANDLED WITH AND WITHOUT USE OF SAFETY COVERS

被引：46

作者：

OESTREICHER, U ^{[1
]}

STEPHAN, G ^{[1
]}

GLATZEL, M ^{[1
]}

机构：

[1] MED SERV CITY KARLSRUHE,W-7500 KARLSRUHE,GERMANY

来源：

MUTATION RESEARCH | 1990年 / 242卷 / 04期

关键词：

Chromosome aberrations; Cytostatic drugs; Lymphocytes; Occupational exposure; Sister-chromatid exchanges;

D O I：

10.1016/0165-1218(90)90045-4

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The frequency of structural chromosome aberrations and sister-chromatid exchanges in peripheral blood lymphocytes of nurses handling cytostatic drugs without a safety cover is compared with that of individuals doing this work exclusively under a safety cover and with that of nurses working under similar conditions but not handling cytostatics. The mean yield of dicentric chromosomes, (4.3 ± 0.7)/1000 cells, and acentric fragments, (15.4 ± 1.4)/1000 cells, in the occupationally exposed group is significantly increased in comparison to individuals working with protection (dic: (1.1 ± 0.4)/1000 cells, ace: (11.2 ± 1.2)/1000 cells) and nurses not handling cytostatics (dic: (2.1 ± 0.5)/1000 cells, ace: (9.9 ± 1.1)/1000 cells). The frequency of chromatid breaks and SCE is not significantly different between these groups (p > 0.05). © 1990.

引用

页码：271 / 277

页数：7

共 22 条

[1] ACUTE AND LONG-TERM CYTOGENETIC EFFECTS OF TREATMENT IN CHILDHOOD-CANCER - SISTER-CHROMATID EXCHANGES AND CHROMOSOME-ABERRATIONS [J].