AN EFFICIENT ROUTE TO ENANTIOMERICALLY PURE ANTIDEPRESSANTS - TOMOXETINE, NISOXETINE AND FLUOXETINE

被引：44

作者：

SCHNEIDER, MP

GOERGENS, U

机构：

[1] Universität- GH-Wuppertal, Fb. 9 org. Chemie

来源：

TETRAHEDRON-ASYMMETRY | 1992年 / 3卷 / 04期

关键词：

D O I：

10.1016/S0957-4166(00)80257-8

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Both enantiomers (R)- and (S)- 3-chloro- 1-phenyl- 1-propanol can be obtained conveniently by an efficient enzymatic resolution process. They can be converted via enantioconvergent routes into all enantiomers of the important antidepressants (R)- and (S)- Tomoxetine, Fluoxetine and Nisoxetine.

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页码：525 / 528

页数：4

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