EFFECT OF INOCULUM SIZE ON BACTERIOLYTIC ACTIVITY OF CEFMINOX AND 4 OTHER BETA-LACTAM ANTIBIOTICS AGAINST ESCHERICHIA-COLI

被引：22

作者：

SORIANO, F

EDWARDS, R

GREENWOOD, D

机构：

[1] UNIV NOTTINGHAM HOSP,QUEENS MED CTR,DEPT MICROBIOL,NOTTINGHAM NG7 2UH,ENGLAND

[2] UNIV NOTTINGHAM HOSP,QUEENS MED CTR,PHLS LAB,NOTTINGHAM NG7 2UH,ENGLAND

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1992年 / 36卷 / 01期

关键词：

D O I：

10.1128/AAC.36.1.223

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

MICs and turbidimetric experiments revealed a negligible inoculum effect with two Escherichia coli strains exposed to cefminox and cefoxitin, whereas a marked inoculum effect was revealed after exposure to cefotaxime, ceftizoxime, and imipenem. The activities of the cephamycins were associated with spheroplast formation and bacteriolysis at concentrations close to the MIC, whereas the other agents induced the formation of filaments or, in the case of imipenem, rounded cells.

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页码：223 / 226

页数：4

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